| abstract |
The present invention relates to a novel process for the preparation of the hydrochlorides of 2- [2-aminoethylthio-methyl] -5-dimethylaminomethyl-furan of formula (I) and, if desired, any of the salts of the salts obtained. known to be converted to a base of formula (I), comprising the 5-dimethylaminomethylfurfuryl alcohol hydride of formula (III) and the hydrochloride of cysteamine at a temperature of from 20 ° C to 120 ° C; without addition of solvent, optionally in the presence of an inert formulation diluent, optionally under a slight vacuum, with a catalytic amount of mineral acid and, optionally, with a catalytic amount of mineral acid and / or a catalytic amount of the above reaction conditions; / 0-2 pKa / organic acid in the presence of a compound, and, if desired, separates the dihydrochloride obtained by any of the processes a / b. and, if desired, the base of formula (I) is liberated and / or, if desired, converted into the monohydrochloride of the base of formula (I) H6n-HC <7ach- (c <-nh2 HjC2O1). h3cx / h3c CH2OH Sitting) -1- |