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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
filingDate 1983-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_467c40b53dbcf38be417c301e6415da7
publicationDate 1987-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber HU-192955-B
titleOfInvention Process for producing a-21978 ccyclic peptide derivatives acilyzed with alkoxy-benzoyl-group
abstract A process for the preparation of A-21978C cyclopeptide derivatives having the formula I resulting from the formula sheet, wherein R is a benzoyl group -OR 2 and X-substituted, in which R is high C 2 C 8-C 15-alkyl and X is Hydrogen, chlorine, bromine, iodine, nitro, C deep 1-C deep 3-alkyl, hydroxy, C deep 1-C deep 3-alkoxy or C deep 1-C deep 3-alkylthio and in which R is high 1 for hydrogen or an amino protecting group, or pharmaceutically acceptable salts thereof, by reacting a corresponding nucleus of A-21978C of Formula I wherein R is hydrogen to give a free amino group and the other two free amino groups either unprotected or optionally protected by a protecting group or a corresponding pharmaceutically acceptable salt thereof with an acylating agent which is the free benzoic acid derivative corresponding to the substituted benzoyl group R or a benzoyl group activated ester thereof. A preferred compound hereafter available is N-deep Trp-p- (n-dodecyloxy) benzoyl-A-21978C.
priorityDate 1982-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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