| abstract |
Phosphorus containing acetic acid derivatives have the general formula (I> <IMAGE> wherein R<3> and R<4> are the same or different and represent hydrogen, halogen, hydroxy, amino, sulphonic acid group or a specified organic group or R<3> and R<4> together represent oxo-, hydroxyimino, O-alkylimino or substituted alkylhydroxyimino, R<5> represents phenyl, substituted phenyl, 1-methyl-tetrazol-5-yl, 2-methyl-1,3,4-thiadiazol-5-yl, 1,3,4-thiadazol-2-yl, 1,2,3-triazol-4-yl, 1-substituted-tetrazol-5-yl, pyrrolidin-2,5-dion-1-yl, sacharyl, 1- phenyl-3-methyl-pyrazol-4-in-5yl, 8-quinolyl or substituted 8-quinolyl or Q<4>R<5> can optionally represent halogen and R<5> can further represent N,N'-optionally substituted amidine in which the carbon atom of the amidine group is attached to Q<4> atom, and R<5> can further represent alkoxycarbonyl, aryloxycarbonyl or aralkyloxycarbonyl, R<6> and R<7> are the same or different and represent hydrogen, an optionally substituted straight or branched chained C1-6 alkyl group C3-6 cycloalkyl, phenyl or an optionally substituted phenyl group Q<1>, Q<2> and Q<3> are the same or different and typically represent O or S, Q<4> stands for O or S, k, m and n individually represent 0 or 1. The compounds of the general formula (I) can be used for the preparation of phosphorus-containing penicillanic/cephalosporin derivatives as acylating agent. Some of the compounds of the general formula (I) have potential use as antibacterial, antiviral, antifungal and herbicidal agents. |