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filingDate 1979-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_135bffe6572a4acc22d407cb4376c1de
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publicationDate 1986-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber HU-188767-B
titleOfInvention Process for producing 7-/trimethylsilyloxi-carbonyl/-amino-3-cepheme-4-carboxylic acid derivatives
abstract In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
priorityDate 1979-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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