| abstract |
2,4-Diamino-5-benzyl-pyrimidine derivatives (antibacterials) of the formula <IMAGE> (R1 and R3 represent hydrogen, a methyl group or a methoxy group; R2 is a halogen, a C1-4 alkoxy group substituted with a halogen, a C2-4 alkenyloxy group or an R4O(R5O)n group; R4 is a C1-4 alkyl group; R5 a C1-4 alkylene group; n is 1 or 2), and their acid addition salts are prepared by reacting an alpha - benzal- beta -methoxypropionitrile of the formula <IMAGE> with a diethylene glycol monoalkyl ether in the presence of a base, cyclising the thus-obtained benzyl isomer of the formula <IMAGE> (preferably without separation) with quanidine and, if desired, converting the product to a salt. |