http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-188160-B
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-36 |
filingDate | 1982-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c1f5b972817503614ef6282534af9c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce89ede9f6801d54b1e6dab26092eb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_417615fa9dfe62b72c89c9b1c73c237c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18158cb802b626a6da5a3a6d34cc9e01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb7f07b7d3c391f9de828d41b7c87c4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5175cc88f7d3ccc439ad513ff86cebdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf813cc4ada75caf77a0b27830b297a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_985d6a6ddfa8712742be3ccfb297a42c |
publicationDate | 1986-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | HU-188160-B |
titleOfInvention | Process for preparing 2-imidazolidinone-1-thiocarvoxylic acid amide |
abstract | The present invention relates to a process for the large-scale production of 2-imidazolidinone-1-thiocarboxylic acid of formula (I) by reacting a rodan of formula (IV) wherein Me is an alkali metal or ammonium and benzoyl chloride, to obtain the benzoyl isothiocyanate of formula (II). Reaction of 2-imidazolidinone, followed by basic hydrolysis of N-benzoyl-2-imidazolidinone-1-thiocarboxylic acid of formula (III), by reacting the rodan of formula (IV) and benzoyl chloride at 0-30 ° C. the resulting benzoyl isothiocyanate of formula (II) is reacted in the reaction mixture formed in its preparation without isolation with 2-imidazolidinone and then in the reaction mixture of the resulting N-benzoyl-2-imidazolidinone-1-thiocarboxylic acid, without isolation. Hydrolyzed at 0-30 ° C with an alkali metal hydroxide from a dipolar aprotic solvent and in a protic solvent. reaction medium. The compound of formula (I) is known as a pharmaceutical intermediate. Our process allows the preparation of the compound of formula (I) to be produced in a substantially better yield, in pure form, and in conditions which can be advantageously carried out in industrially acceptable conditions. NH N - CZ '11 0> 0' N = C = θ CH 1, - CH 1 x nh-c s N NH xc / I 0 Me-SCN IV -1- |
priorityDate | 1982-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.