| abstract |
The invention relates to a process for the preparation of novel aminoacridine-alpha, beta- (D) - and - (L) -N-glycoside derivatives of the formula I, which are distinguished from known aminoacridines by a lower toxidity, greater stability and better compatibility and thus have valuable pharmacological properties. In formula I, n is 0.1; p: 1, 2, 3; A: anion, preferably halogen, R is hydrogen or -NR high 1 -R high 2 with R high 1 = H or methyl and R high 2 = H or sugar residue and X -NR high 1 -R high 2 H, halogen, alkyl, Alkoxy, nitro, cyano carbomethoxy, carbamoyl, phenyl or alkylphenyl, wherein of R and the two X at least one substituent -NR is high 1-sugar residue and R is highly H 3 or alkyl. For example, 3,6-di (beta-D-glucopyranosyl-amino-acridine is prepared by suspending D-glucose monohydrate and 3,6-diaminoacridine hydrochloride in a mixture of acetone and water and adding hydrochloric acid. |