| abstract |
The invention relates to processes for the preparation of proline derivatives of the general formula in which R represents a hydroxyl group or a lower alkoxy radical and X represents a chlorine, bromine or iodine atom or a tosyloxy group, by acylating L-proline or its lower alkyl ester with, for example, a Halocarboxylic acid of the general formula in which X is a chlorine, bromine or iodine atom. {Preparation of proline derivatives; Intermediates; Drug ingredient; captopril} |