http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-184918-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a157f5faa443ba5bb3367371f1e2a6c7 |
| filingDate | 1980-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90f629bfd27947ac29e3a583b10774d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_312d8c97597a5d838bf8f7c7eeb52bc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_348f418053d4fb8a8be0b29727c5301f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cea70b0d3752555a1538e738e6a699c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14ddbab79c7415c0b20b7de0d873a11c |
| publicationDate | 1984-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-184918-B |
| titleOfInvention | Process for producing simultaneously pgf-2 down alpha derivatives substituted at the 4 or 7 position |
| abstract | FIELD OF THE INVENTION The present invention relates to novel substituted PGF? Derivatives of the general formula I and II, wherein R is hydrogen, an alkali metal cation, optionally one to four identical or different C 1-4 alkyl substituted ammonium cations or a C 1 -C 4 alkyl group, R 1. * hydrogen atom or C 1-4 alkanoyl, R 2 and R 3 are hydrogen, C 1-4 alkanoyl, tetrahydropyranyl, benzoyl, or tri- (C 1 -C 4 alkyl) silyl, R 4 hydroxyl, halogen, methanesulphonyloxy or toluenesulphonyloxy or R 1 and R 4 together may represent a -C (C 1 -C 4 alkyl) 2 -O group, R 5 a hydroxyl group, a halogen atom, a methanesulphonyloxy group or a toluenesulphonyloxy group, and 2 a? According to the present invention, a PGF2a derivative of formula III is optionally hydroxylated with a selenium compound 5 of +4 in the presence of hydrogen peroxide, followed by the novel substituted PGF2a isomers of formula I and II, wherein R4 is hydrogen. and R5 represents a hydroxyl group 10, if desired, by hydrolysis, acylation, acetylation or salt formation to form another compound of formula I and II and / or, if desired, isolating the isomers I and II. Compounds of formulas I and II exhibit a therapeutic effect similar to PGF2a and are useful, for example, for the synthesis of prostacycline derivatives as starting materials. 184 918 |
| priorityDate | 1980-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.