| abstract |
The invention relates to a process for the preparation of indole derivatives for use as medicaments for the treatment of ischemic heart disease, stroke, thrombosis, migraine and Gefaeszkomplikationen in diabetes. The aim is to provide a compound which inhibits the action of thromboxane synthetase and prevents the aggregation of blood platelets without affecting the vasodilator effect of prostacyclin synthetase or cyclooxygenase. The invention provides compounds of formula I wherein, for example: R & exp 1! Hydrogen or C & ind 1! -C & ind 4! -Lower alkyl, R & exp2! Hydrogen, C & ind 1! -C & ind 6! -Alkyl, C & ind 3! -C & ind 6! -Cycloalkyl and the like, R & exp 3! In which n is 1 to 3, Y is COOR & exp 4 !, CONHR & exp 5 !, CONHCN ua, R & exp 4! Hydrogen or C & ind 1! -C & ind 4! -Lower alkyl, R & exp 5! Hydrogen, C & ind 1! -C & ind 4! -Lower alkyl, C & ind 3! -C & ind 6! -Cycloalkyl and the like, as well as their pharmaceutically acceptable acid addition salts and bioprecursors. |