| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acda4db875819409a75c9189cd9127f7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 |
| filingDate |
1982-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87331981dbc350f46c29ac17adcef295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c805cb9c0ad04f54dcff8057a955f9f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a43dca4e54ca7f349ed17856fb613449
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd44d4bd59c7eb46c1b96e06256e9f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbb322b1923b1fe1cf0cb1cc3b54f178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13b1508dcc105d2e6dac9e98beeb30a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e8ae064876e77b4c5c5df7ff1a42b8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18fbac160c9a13a60a82294fd7b22721
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8db0d884b57e9d48ed3c615f7243957b |
| publicationDate |
1984-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
HU-184513-B |
| titleOfInvention |
Process for preparing prostaglandin-f down 2 alpha-derivatives |
| abstract |
A process for producing F2 alpha prostaglandin and analogues thereof, in which a lactone diol or the C-15 epimer thereof is reacted with a 1-alkoxybenzyl halide in a solution of an aromatic hydrocarbon in the presence of a tertiary amine, at a temperature of - 20 to 40 DEG C and in a molar ratio of reacting components of 1.0: 1.0 to 1.1. The protected lactone is then reduced with a complex hydride at a temperature of - 80 to 20 DEG C. The lactol or C-15 epimer obtained by this reduction is then reacted with an "ylide" in a polar aprotic solvent to give the bisacetal of prostaglandin or the C-15 epimer thereof. The desired product is obtained using a 0.4 to 2 N oxalic acid solution or after isolation with a cation exchanger, in an aqueous medium with 10 to 80% by weight of an alcohol having 1 to 4 carbon atoms at a temperature of 20 to 80 DEG C. F2 alpha prostaglandin and analogues thereof are biologically active and are used in human and veterinary medicine. |
| priorityDate |
1981-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |