abstract |
Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60≰C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl. |