| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 |
| filingDate |
1976-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef39d4b53227820c53779d47da77bcaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7288159582f2e7f65dd8a0469aa775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654afb8d4a0211d93bb3d84da449abd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92b5dbdbb2968008aeb158620c8ee760
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d691171c348fa34778e2c3282d15f607 |
| publicationDate |
1984-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
HU-183048-B |
| titleOfInvention |
Process for producing bracket-2s,3r-bracket closed-, bracket-2s,3s-bracket closed-, bracket-2rs,3r-bracket closed- or bracket-2rs,3rs-bracket closed-3-amino-2-hydroxy-propionyl-glycine derivatives |
| abstract |
For preparing the novel bestatin compounds of the formula <IMAGE> having R1 and R2 in accordance with the preceding Patent Claim 1, an alpha -hydroxybeta -amino acid of the formula <IMAGE> is used as the starting material. The latter is condensed, optionally after having protected the functional groups which are not to participate in the subsequent reaction, with a beta -amino acid of the formula <IMAGE> using a peptide-linking method. Protective groups which may optionally be present are subsequently removed. The optically pure diastereoisomers can be readily obtained from the compounds of the formula (III). The alpha -hydroxybeta -amino acids can be prepared by hydrolysing a corresponding cyanohydrin whose amino group is optionally protected. The novel compounds inhibit certain enzymes which decompose bleomycin and in this way amplify the anti-tumour activity of the bleomycins. |
| priorityDate |
1975-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |