| abstract |
The invention relates to a process for the preparation of imidazole derivatives, in particular of certain N- (phenoxyalkyl) -imidazoles, which are substituted in the phenyl ring with acidic and polar groups. For example, to prepare 1- & 2- (4-carbamyophenoxy) ethyl! -Imidazole, sodium hydride is reacted with imidazole and N, N-dimethylformamide. After completion of the reaction, an addition of 4- (2-chloroethoxy) benzamide. The compounds of the invention are capable of inhibiting the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclo-oxygenase enzymes. The inventive compounds can therefore be used, for example, in the treatment of thrombosis, ischemic heart diseases, strokes, transient ischemic disorders, migraines and in the case of vascular complications of diabetes. |