http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-182432-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-00 |
| filingDate | 1978-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9bd313d852a9f2625cfac050363f2bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52c201fd4a2314a529451b07a5ee3826 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f27161fc949293bd9ec7ee2536305ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41e04ade255a6d664a98b2011345b48f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb3729b65365bcb045a0eea5415c2ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ce47223b27bfb76b237dc27cb6e14c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71852dbd12d8e0d35992e7aa0aa1adac |
| publicationDate | 1984-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-182432-B |
| titleOfInvention | Process for producing new 9-halogeno-1-alkyl-1-alkyloxycarbonylethyl-oktahydro-indoloquinolysines |
| abstract | The present invention relates to novel racemic and optically active 9-halo-1-alkyl-1-alkyloxycarbonylethyl octahydroindolokinolysis of formulas Va and Vb, wherein R2 and R3 are C1-C4 alkyl, X is halogen and is pharmaceutically acceptable. for the preparation of their acid addition salts by selectively reducing the novel Va and Vb after converting the novel 9-halo-1-alkyl-1-alkoxycarbonylethylhexahydro-indolokinolizinium alkoxide of formula IVa, if desired, to the acid addition salt of formula IVb. 9-halo-1-alkyl-1-alkyloxycarbonylethyloctahydroindolokinolysine isomer is separated into isomers, or hydrolysed first, and the resulting carboxylic acid isomer is separated into isomers, and each isomer is then esterified and, if desired, racemic Va or Vb obtained by any of the above methods The compound of formula (nos) is resolved and / or converted into a pharmaceutically acceptable acid addition salt. The importance of the novel 9-halo-1-alkyl-1-alkyloxycarbonylethyl-octahydroindoloquinolizines of formula Va and Vb and their acid addition salts is an important intermediate of the 10-halo-vincamic acid esters with valuable therapeutic properties, which in the old age are cerebral vessels. are particularly suitable for the treatment of behavioral disorders caused by damage and calcification. fif 20 25 30 182432 Αθ H R30r-CH2-CH2-x1x2 R2 IVb -1- |
| priorityDate | 1978-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.