| abstract |
The invention relates to a process for the preparation of novel 1,2,4-oxadiazine derivatives of the formula I in which the meaning of the substituents and of n and m must be taken from the claim. The new compounds, for example of 3-phenyl-6- (1,2,3,4-tetrahydro-2-isoquinolyl) -methyl-5,6-dihydro-4H-1,2,4-oxadiazine, have a strong and persistent peripheral vasodilatory and hypotensive effect on. In addition to its anti-inflammatory and diuretic effect and its antiarrhythmic effect is very pronounced. For example, by reacting 3-phenyl-6-chloromethyl-5,6-dihydro-4H-1,2,4-oxadiazine with 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline, the 3-phenyl -6- (6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolyl) -methyl-5,6-dihydro-4H-1,2,4-oxadiazine. |