http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-180095-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-234 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-236 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-224 |
| filingDate | 1978-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5027dd5a560276b58f068162086b0023 |
| publicationDate | 1983-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-180095-B |
| titleOfInvention | Process for producing selectively protected aminoglycosides |
| abstract | This invention relates to the selective N-protection of aminoglycosides and to novel, selectively protected aminoglycoside intermediates. Modifications in aminoglycoside molecules are usually accomplished by multi-stage reactions whereby in most cases amino groups need to be protected in order to avoid side reactions. To obtain 1-N-alkyl- and 1-N-acyl- substituted- 4,6-di-O- (aminoglycosyl) -1,3-diaminocyclitols which are very potent antibiotics, ideally all other amino groups are protected before introduction of the 1-N-substituent into the 4,6-di-O- (aminoglycosyl) -1,3-diaminocyclitol. A process is provided for the selective protection of the 3"-amino function in a 1,3"-di-N- unprotected-poly-N- protected -4,6-di-O- (aminoglycosyl) -1,3-diaminocyclitol, wherein the 6-0-aminoglycosyl has an amino function at the 3"-position and hydroxyl functions at the 2" and 4" positions. Also, the respective 1-N-unprotected-poly-N- protected -4,6-di-O- (aminoglycosyl) -1,3-diaminocyclitol intermediates are described. n Selective protection of the 3"-amino function is accomplished by reaction with no more than one molar equivalent of available 1-Z-imidazole wherein Z is an amino protecting group. |
| priorityDate | 1977-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.