abstract |
A method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline comprising heating a N-chloro-, N-bromo- or N-hydroxyethyl-2,3-dichlorobenzylamine in an aluminum chloride melt at 160 to 210°C. A novel N-chloroethyl-, N-bromoethyl or N-hydroxyethyl- 2,3-dichlorobenzylamine intermediate is used as starting material for the cyclization. |