http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0700411-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9a36328274867f46f8fc1fb9c868703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 |
| filingDate | 2007-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8d749b1c9a4a02fdad42390ec7412f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c78c42f22fbcf119cf205ab22e5df1c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e7058a248d346c7d74d9426fdcbf3fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f06d6225ca53cda84b4a038af365c11 |
| publicationDate | 2009-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0700411-A2 |
| titleOfInvention | Process for producing quetiapine |
| abstract | Process for the synthesis of 2-[2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-piperazine-1-yl)-ethoxy]-ethanol of formula (I) (quetiapine) by reacting the 1-oxodibenzo-[b,f][1,4]thiazepine of formula (II) with phosphorus oxychloride by d) using 1-6 molequivalent of phosphorus oxychloride in an inert solvent and the obtained 11-chlorodibenzo[b,f][1,4]thiazepine compound of formula (IV) without isolation; e) is reacted further in an inert solvent in the presence of a base with 2-[2-(1-piperazinyl)-ethoxy]-ethanol dihydrochloride of formula (III a) or dihydrochloride monohydrate of formula (III b), in the mixture of an inert non-polar and dipolar aprotic solvent; f) in desired case the isolated quetiapine base of formula (I) is reacted with fumaric acid to form the hemifumarate salt thereof. |
| priorityDate | 2007-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.