| abstract |
The present invention relates to tri-ring compounds having the heterocyclic substituents of the general formula wherein n1 and n2 are independently 0-2; Het is an optionally substituted mono-, di- or tri-ring heteroaromatic group; B is alkyl or optionally substituted alkenyl; R22 -COR23 or a carboxy, sulfinyl, sulfonyl, sulfonamide or amino acid derivative; R23 is alkyl substituted by halogenated alkyl, alkenyl, halogenated alkenyl, alkynyl, optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl or -COOH and / or SO3H; R 1, R 2, R 3, R 9, R 10 and R 11 are conventionally optionally substituted substituents in organic chemistry and for the treatment of diseases associated with thrombosis, arteriosclerosis, restenosis, hypertension, myocardial pain, arrhythmia, heart failure and cancer. The invention further relates to compounds of the general formula wherein W is 3-trifluoromethylphenyl, 3-fluorophenyl, 2,3-difluorophenyl, 3-chlorophenyl, 2-chlorophenyl or 2,3-dichlorophenyl, Z is oxygen, sulfur , N 2, SO 2, SO 2, NH or N, substituted with methyl, alkylcarbonyl, benzene or aminocarbonyl. |