| abstract |
The present invention relates to novel compounds of the general formula GSK3 inhibitory activity, wherein preferably Z and X are nitrogen or methine; Y is -CO-NH-; P is phenyl, furyl or thienyl; At least one nitrogen-containing heteroaromatic group, preferably a pyridyl group; R is optionally substituted sulfamoyl, sulfamoylalkyl, carbamoyl, carbamoylalkyl, (alkoxycarbonyl) alkyl, aminoalkyl, aminoalkoxy or heterocyclyloxy; R3 and R4 are halogen, alkyl, trifluoromethyl, trifluoromethoxy, or optionally substituted amino or aminoalkyl; and m and its derivatives are 0, 1 or 2 and their salts, their pharmaceutical compositions, processes for the preparation of the compounds of the formula I and the novel intermediates prepared in connection therewith. HE |