| abstract |
The present invention relates to aryl-substituted pyridine derivatives of formula (I), or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R is optionally substituted alkyl, or a pharmaceutically acceptable salt thereof. -, amino, alkylthio, -C (O) R 10, -SO 2 R 10 or -OC (O) NH 2; R2 is -Ym- (CH2) nZ wherein Y is -O, -S-, or NR11 where R11 is hydrogen or alkyl, Z is a saturated heterocyclic group which may be optionally substituted on one or more carbon atoms, m is 0 or 1, and n is 0-6; R3 and R4 are independently hydrogen, optionally substituted alkyl, alkenyl and / or alkynyl, halogen, hydroxy, cycloalkyl, cyano, amino, alkylamino, dialkylamino, alkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl; aralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino and / or aralkylcarbonylamino. The present invention also provides the use of a compound of formula (I) for the treatment of global and focal ischemic neuronal loss, for the prevention or treatment of neurodegenerative conditions such as lateral sclerosis (ALS), for the treatment of acute , an anti-manic agent, a local anesthetic and / or an antiarrhythmic agent. HE |