| abstract |
The present invention relates to a compound of the general formula wherein M is [C (R30) (R40)] m, wherein m = 1-6; Substituted alkyl, optionally substituted cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, cyano, -OR3, -C (O) R4, -C (O) OR3, -C (O) NR24R25 , -C (O) NR 24 OR 3, -C (O) SR 3, -NR 24 R 25, -NR 25 C (O) R 4, -NR 25 C (O) OR 3, -NR 25 C (O) NR 24 R 25, -NR 25 C (O) NR 24 OR 3, -SR 3, - S (O) x NR 24 R 25, -S (O) x NR 25 OR 3, -P (O) (R 24) (OR 24) -P (O) (OR 24) (OR 24) -C (R 4) [= N (OR 3)], -C (O) AA-NR24R25 or -C (O) AA-NR25OR3; V optionally substituted alkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, cyano, -OR3, -C (O) R4, - (CR23R24) n1-C (O) OR3 , -C (O) NR 24 R 25, - (CR 23 R 24) n 1 -C (O) NR 25 OR 3, -C (O) SR 3, -NR 24 R 25, -NR 25 C (O) R 4, -NR 25 C (O) OR 3, -NR 25 C (O) NR 24 R 25 , -NR 25 C (O) NR 24 OR 3, -SR 3, -S (O) x NR 24 R 25, -S (O) x NR 25 OR 3, -P (O) (R 24) (OR 24) -P (O) (OR 24) (OR 24), -C (R4) [= N (OR3)], -C (O) AA-NR24R25 or -C (O) AA-NR25OR3; W is a covalent bond, -C [(R 3) (R 4)] n 2 -, -O-, -S- or -N (Z) -; X is optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene or -C? C; U is a covalent bond, - [C (R 3) (R 4)] p-, -Y- [C (R 3) (R 4)] q -, - [C (R 3) (R 4)] t -Y or -Y-; n = 0-2; R1 is optionally substituted alkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, -C <CR3 or -CR3 = CR4R4; R2 is hydrogen, halogen, optionally substituted alkyl, R22-substituted alkyl, \ t cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, -OR6, -C (O) R7, -C (O) OR6, -NR24R25, -NR24 (CO) R25, -N (= CO- R24R25) or -NR24S (O) 2R25- and their salts, solvates, isomers, uses and pharmaceutical compositions thereof. HE |