abstract |
The present invention relates to compounds of the general formula wherein G is mono- or polycyclic aryl or heterocyclic; E C = Z 2, CR 7 CR 7 ', -SO 2 -, -P = OR 2 or -P = OOR 2; Z1O, S, NH or NR6; Z2 is O, S, NH or NR6; A1 CR7 or N; A2 CR7 or N; YJJ '-J', where J- (CR7R7 ') n- and n = 0-3, J', O, S, S = O, SO2, NH, NR6, C = O, OC = O, NR1C = O, CR7R7 ', C = CR8R8', R2P = O, OPOOR2, OPO2, OSO2, C = N, NHNH, NHNR6, NR6NH, N = N, optionally substituted cycloalkyl, cycloalkenyl, heterocyclyl or aryl, and J '- (CR7R7') n- and n = 0-3, where Y is other than bond, CR7R7'-CR7R7 ', CR8 = CR8, CR7R7'C = O, NR9-CR7R7', N = CR8, N = N , NR9-NR9, optionally substituted cycloalkyl, cycloalkenyl, heterocyclyl or aryl, QH, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, arylalkyl, alkynyl or aryl or other complex substituent; M bond, O, CR7R7 'or NR10 and M' bond or NR10 with the proviso that at least one of M or M 'is a bond; L bond, (CR7R7') n, NH, NR5 or N (CR7R7 ') n where n = 0-3; R1-R10H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, arylalkyl, alkynyl or aryl, or other substituent and pharmaceutical compositions containing them and their manufacture. HE |