| abstract |
The present invention relates to substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use as a medicament. In the formula (1), R 1 is C 7 -C 22 alkyl, 2-4 Comosalkalkalkyl substituted with C 4-20-20-20 alkalkoxy, C-10-10-10-10-10 ar aryl, C 6-10-10 ar ar aryloxy, or C 4-12alkalkalkoxy) C 2-444 alkoxy, and may be C 7-20-20alkalkalkenyl; , 3b-cholestan-3-yl or substituted phenyl; R2, R3, R4 and R5 are hydrogen or halogen, nitro, C1-C4 alkyl, C1-C9 alkoxy, trifluoromethyl, trifluoromethoxy or (C6-C10 aryl) - (1- C 4 -C 6 alkoxy), C 6 -C 10 aryloxy, C 6 -C 10 aryl, C 3 -C 8 cycloalkyl, or O- (C 3 -C 8) cycloalkyl, each of which may be substituted. The invention relates to the preparation of compounds. The compounds of formula (I) inhibit pancreatic lipase and can be used as anti-obesity agents. SHE |