| abstract |
FIELD OF THE INVENTION The present invention relates to the use of the compounds of the formula I and their pharmaceutically acceptable salts, to pharmaceutical compositions containing them and to the manufacture of a medicament for the treatment or prevention of acute, subacute and chronic thrombotic disorders in mammals. In the formula (I), A is aryl, substituted aryl, monocyclic heteroaryl, or substituted monocyclic heteroaryl; B is optionally substituted -NH-C (= O) -alkyl, -NH-C (= O) -cycloalkyl, -NH-C (= O) -Oalkyl, -C (= O) -R 1, cycloalkyl, heterocycloalkyl , cycloalkenyl, unsaturated heterocyclo, aryl or heteroaryl; C is optionally substituted phenyl or heteroaryl; G is hydrogen or halo or alkyl, haloalkyl, hydroxyalkyl, -CH2Oalkyl, -CH2-CO2alkyl, -CH2-NR2R2 'or -CH2CONHalkyl; W1 is a saturated or unsubstituted, substituted or unsubstituted hydrocarbon chain or a hydrocarbon heteroatom chain containing from 2 to 6 atoms, wherein W1 connects the 1-nitrogen to the 2-carbon to form a 4- to 8-membered ring; R 1 is alkoxy, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, monocyclic heteroaryl, or -NR 3 R 4; R2 and R2 'are independently hydrogen or alkyl; and R3 and R4 each independently represent hydrogen, alkyl, aralkyl, aryl, monocyclic heteroaryl, alkoxycarbonyl, aralkoxycarbonyl or -SO2alkyl, or together form a saturated or unsaturated 3- to 7-membered ring. SHE |