| abstract |
Within the scope of the present invention are compounds of formula I wherein R 1 is alkyl or alkenyl, R 2 and R 3 are independently hydrogen or alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl, or R 2 and R 3 taken together with the adjacent nitrogen atom are substituted or unsubstituted. a saturated heterocyclic group containing nitrogen, X, Y and Z independently of one another hydrogen, alkyl, halogen or the like, and a represents an integer from 1 to 5; salts thereof and pharmaceutical compositions containing them. The compounds of the invention have inhibitory activity against IL-1b, are well water soluble and have good oral absorption. HE |