| abstract |
The compounds of the present invention in the general formula (I) are selected from the group consisting of pyridyl, pyrimidinyl, pyrazinyl and pyridazinyl, R1 being hydrogen, aryl, formyl, alkylcarbonyl, alkyl, alkyloxycarbonyl, formyl, alkylcarbonyl, alkyloxy, alkyloxy, alkyloxy, NR 1 -, -NH-NH-, -N = N-, -O-, -C (= O) -, -C (= S) -, -OC (= O) -, -C (= O) - O-, -OC = O- (alkyl) -, -C (= O) -O- (alkyl) -, -O- (alkyl) -C (= O) -, -C (= O) - (alkyl) ) -O-, -OC (=) - NR 1 -, -NR 1 -C (= O) -O-, -OC (= O) -C (= O) -, -C (= O) -NR 1 -, -NR 1 -C (= O) -, -C (= S) -NR 1 -, -NR 1 -C (= S) -, -NR 1 -C (= O) -NR 1 -, -NR 1 -C (= S) -NR 1 -, -NR 1 -S (= O) -NR 1 -, -NR 1 -S (= O) 2 -NR 1 -, - (alkyl) -C (= O) -NR 1 -, -O- (alkyl) - C (= O) -NR 1 -, - (alkyl) -OC (= O) -NR 1 -, - (alkyl) -, -O- (alkyl) -, - (alkyl) -O-, -NR 1 - (alkyl) ) -, - (alkyl) -NR 1 -, -NR 1 - (alkyl) -NR 1 -, -NR 1 - (alkyl) (cycloalkyl) - , - (alkenyl) -, - (alkynyl) -, -O- (alkenyl) -, - (alkenyl) -O-, -NR 1 - (alkenyl) -, - (alkenyl) -NR 1 -, -NR 1 - (alkenyl) ) -NR 1 -, -NR 1 - (alkenyl) - (cycloalkyl) -, -O- (alkynyl) -, - (alkynyl) -O-, -NR 1 - (alkynyl) -, - (alkynyl) -NR 1 -, - NR 1 - (alkynyl) -NR 1 -, -NR 1 - (alkynyl) - (cycloalkyl) -, -O- (alkyl) -O-, -O- (alkenyl) -O-, -O- (alkynyl) -O- , -CHOH-, -5-, -S (= O) -, -S (= O) 2 -, -S (= O) -NR 1 -, -S (= O) 2 -NR 1 -, -NR 1 - S (= O) -, -NR 1 -S (= O) 2 -, -S- (alkyl) -, - (alkyl) -5-, -S- (alkenyl) -, - (alkenyl) -5-, -S- (alkynyl) -, - (alkynyl) -S- or -O- (alkyl) -S - (= O) 2 - or a direct bond, Z is a direct bond, alkanediyl, alkenediyl, alkindyl, oxygen or sulfur, carbonyl, carbonyloxy, oxylcarbonyl, thiocarbonyl, sulfinyl or sulfonyl, -O- (alkyl) -, -NR 1 -, -NR 1 - (alkyl) -, -NR 1 -C (= O) -, - OC (-O) -NR 1, -NR 1 C (= O) -O-, NR 1 -C [-S] -, -S [= O] -NR 1 -, -S (= O) 2 -NR 1 -, -NR 1 -S (= O) - -NR 1 -S (= O) 2 -NR 1 - (C = O) -NR 1 -, -NR 1 -C (= S) -NR 1 -, -NR 1 -S (= O) -NR 1 - or -NR1-S (= O) 2-NR1-; R 2 is hydrogen, alkyl, alkenyl, alkynyl or R 2, which may be optionally substituted with one or more substituents, R 3 is hydrogen, hydroxy, halo, alkyl, cyano, hydroxy or -C (= O) -R 1 substituted alkyl. , alkenyl, alkenyl substituted with one or more halo or cyano, alkynyl, alkynyl substituted with one or more halo or cyano, alkyloxyalkyl, alkyloxyalkyl, polyhydroxy, alkyloxy, alkyloxy, alkyloxy, alkyloxy, |