| abstract |
The present invention relates to compounds of formula I and their pharmaceutically acceptable salts, solvates or stereoisomers, and to pharmaceutical compositions containing them; the invention also relates to the use of the compounds for the preparation of a medicament. The compounds and compositions of the present invention are useful for the inhibition of b2 adrenergic receptor activity, and thus for the treatment of diseases or conditions related thereto in mammals, such as asthma or chronic obstructive pulmonary disease, neurological disorders, cardiac disorders and inflammatory diseases. The substituents in formula (I) are of a wide variety, such as, for example, each of R 1 to R 5 is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl and R a; or R 1 and R 2, R 2 and R 3, R 3 and R 4 or R 4 and R 5 together form, for example, one of the following groups; -C (Rd) = C (Rd) C (= O) NRd-, -CRdRd-CRdRd-C (= O) NRd-, -NRdC (-O) C (Rd) = C (Rd) -, -NRdC (= O) CRdRd-CRdRd, R6 is hydrogen, alkyl or alkoxy; R7 is hydrogen or alkyl; R8 is hydrogen or alkyl; or R 8 together with R 9 form a -CH 2 - or -CH 2 CH 2 - group; R9 is selected, for example, from alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl and Ra; R10 is hydrogen or alkyl; R11, R12 and R13 are selected, for example, from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, -NO2, halogen, -NRdRe; or wherein alkyl, alkenyl and alkynyl of R 1 -R 6, R 9, and R 11 -R 13 may be optionally substituted; w is 0, 1, 2, 3 or 4. Oh |