http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0401715-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f7b665fb8f15d0e2b0911539d39f8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2002-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d1c163118f19318f48fdef719f408ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da65f85945b4ad3430f65230adeee852 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06bcfd3fa29cfff2520151033861393e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00da3c15cd0c0407572c43b41f80643a |
| publicationDate | 2005-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0401715-A2 |
| titleOfInvention | Process for the preparation of racemic and enantiomerically pure 1,5-diaryl-3-trifluoromethyl-delta-2-pyrazole derivatives |
| abstract | The present invention relates to compounds of formula (I) which include racemic mixtures of (+) - 1 and enantiomerically pure compounds of (-) - 1 and (+) - in formula (1) R2 and R3 have the same or different meaning. hydrogen, chlorine or fluorine, or methyl, trifluoromethyl or methoxy; R2 is hydrogen, chlorine or fluorine, or methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylsulfonyl or aminosulfonyl; R4 is hydrogen, chloro or fluoro, or methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylsulfonyl or aminosulfonyl; with that restriction; that one of R2 and R4 is methylsulfonyl or aminosulfonyl. According to the present invention, a racemic mixture of (+) - 1 is prepared by reacting an (E) -1,1,1-trifluoro-4-aryl-3-buten-2-one- is reacted with a phenylhydrazine derivative of the formula (II), with the resulting pyrazoline derivative chlorsulfonic acid, then with sodium hydroxide and finally with thionyl chloride. The pyrazoline derivative obtained by one of the reactions mentioned above is reacted with ammonium carbonate or ammonia, or with pentodium sulphite and methyl iodide or methyl sulphate. and then reacting each of the enantiomers with its sodium salt, the latter being reacted with thionyl chloride, then sodium sulfate and methyl iodide or methyl sulfate to give the enantiomerically pure compounds of the general formula (-) - 1 and (+) - 1, respectively. SHE |
| priorityDate | 2001-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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