| abstract |
The present invention relates to compounds of formula I wherein R1 is phenylvinyl, optionally substituted phenyl, naphthyl, tetrahydronaphthyl or heterocyclic; R 2 is hydrogen or alkyl, and R 3 is optionally substituted phenyl or heterocyclic; or R2 is optionally substituted phenyl or heterocycle, and R3 is hydrogen; R4 is optionally substituted carbamoyl or thiocarbamoyl, phenylcarbonyl, thiazolecarbonyl or pyridylcarbonyl; R5 is optionally substituted aminomethyl. The compounds show affinity for bradykinin receptors and are selective for B1 receptors; for use in the manufacture of pharmaceutical products useful in the treatment or prevention of inflammatory pathologies and chronic or chronic inflammatory diseases. The present invention also relates to a process for the preparation of compounds of formula I and intermediates thereof. HE |