| abstract |
The present invention relates to a process for the preparation of [7-phenyl-6- (4-chlorophenyl) -2,2-dimethyl-2,3-dihydro-1H-pyrrolizin-5-yl] -acetic acid (I). By reaction of 3, 3-dimethyl-3,4-dihydro-2H-pyrrole (III) with 2-bromo-1- (4-chlorophenyl) -ethanone, followed by 7-phenyl-6- (4-chlorophenyl) - 2,2-dimethyl 2,3-dihydro-1 H -pyrrolizine (II) by introducing an acetic acid group. 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by hydrogenation of 5-phenyl-2,2-dimethyl-4-oxo-valeronitrile (N) or a ketal thereof. The invention also relates to processes for the preparation of intermediates in the above process. HE |