| abstract |
The present invention relates to novel positive allosteric AMPA receptor modulators of the formula wherein R1 is hydrogen, alkyl or benzyl; R2 and R3 are the same or different and are hydrogen or alkyl; or R1 and R2 together are a butylene bridge; and R 4, R 5 are the same or different and are optionally substituted with one or more halogen atoms, halogen, cyano, nitro, carboxy, (C 1 -C 6) alkyl-C (= O) -, (C 1 -C 4) alkyl - C (= O) -O-, (C 1 -C 4 alkyl) -OC (= O) -, (C 1 -C 4 alkyl) -OC (= O) -O-, R 6 R 7 N -C (= O) -, hydroxy. -, (C 1-6 alkyl) -O-, (C 1-6 alkyl) -S-, R 6 R 7 N; n and mazonic or different and have a value of 0, 1 or 2, and their use and pharmaceutical compositions containing the compounds. HE |