| abstract |
The present invention relates to 2-iminopyrrolidine derivatives of the formula I wherein B is a benzene ring, a pyridine ring and the like; R101-R103 are hydrogen, halogen, (C1-C6) alkyl and the like; R5 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl, and the like; R 6 is hydrogen, C 1-6 alkyl, C 1-6 alkoxycarbonyl, and the like; Y1 is a bond, -CH2- and the like; Y2 is a bond, -CO- and the like; and Ar is hydrogen or a group of the formula II wherein R 10 -R 14 are hydrogen, C 1-6 alkyl, hydroxy, C 1-6 alkoxy and the like; R11 and R12 or R12 and R13 together can form a 5-8 membered heterocyclic ring. The present invention also encompasses pharmaceutical compositions containing salts of the compounds, compounds and their use. HE |