| abstract |
The compounds of the invention, i.e., 2- [3,5-bis (trifluoromethyl) phenyl] -N- [6- (1,1-dioxo-16-thiomorpholin-4-yl) -4-o- tolylpyridin-3-yl] -N-methyl isobutyramide and 2- [3,5-bis (trifluoromethyl) phenyl] -N- [6- (1,1-dioxo-16-thiomorpholine-4) -yl) -4- (4-fluoro-2-methyl-phenyl) -pyridin-3-yl] -N-methyl-isobutyramamide for the manufacture of medicaments for the treatment of migraine, rheumatoid arthritis, asthma, bronchial hyperresponsiveness, inflammatory bowel disease, or Parkinson's disease , anxiety, depression, pain, headache, Alzheimer's disease, multiple sclerosis, edema, allergic rhinitis, Crohn's disease, eye injuries, inflammatory eye diseases, psychosis, motion sickness, vomiting, vomiting, urticaria, or urine withdrawal symptoms, traumatic brain injury or benign prostatic hyperplasia. The present invention relates to the preparation of compounds and pharmaceutical compositions containing them. SHE |