| abstract |
The present invention relates to novel pharmaceutically active compounds and pharmaceutically acceptable salts and esters thereof. In addition, the invention relates to a pharmaceutical composition comprising said compounds as an active ingredient. The compounds of the invention are potent inhibitors of the Na + / Ca2 + ion exchange mechanism. The present invention relates to a compound of formula (I) wherein X is -O-, -CH2- or -C (O) -; Z is -CHR 9 - or a bond; Y is -CH2-, -C (O) -, CH (OR10) -, -CH (NR11R12) -, -O-, -S-, -S (O) - or -S (O2) -, with bonding that when Z is a bond, Y is different from C (O); the dotted line represents an optional double bond wherein Z is -CR9- and Y is -CH-, C (OR10) - or -C (NR11R12) -; R1 is also - (CH2) nNR4R7 or one of the following groups: n is 1-4, R2 and R3 are independently hydrogen, lower alkyl, lower alkoxy, -NO2, halogen, -CF3, -OH, -NHR8 or -COCH, R4 and R7 are independently hydrogen, lower alkyl or lower hydroxyalkyl, R5 is hydrogen, lower alkoxy, -CF3, -NH2 or -CN, R6 is -NO2, -NR14R19, -CF3 or R8 and R16 is independently hydrogen or acyl, R9 is hydrogen or lower alkyl, R10 is hydrogen, alkylsulfonyl or acyl, R11 and R12 are independently hydrogen, lower alkyl or acyl, R13 and R18 are independently hydrogen or -OR20, R14 and R19 are independently hydrogen, acyl , alkylsulfonyl, C (S) NHR 17 or C (O) NHR 17, R 15 is hydrogen or NH 2, R 17 is hydrogen or lower alkyl, R 20 is hydrogen or acyl and pharmaceutically acceptable salts and esters thereof. HE |