| abstract |
The present invention relates to novel aryloxime piperazines of the general formula wherein X is halogen, -CF 3 or -OCF 3; R1 and R2 are various optionally substituted groups - the processes for their preparation and pharmaceutical compositions containing them. The compounds are CCR5 antagonists and are useful as active ingredients in pharmaceutical compositions for the prevention of HIV infection and for the treatment of HIV infection and AIDS. One effective compound of the invention has the following chemical structure: Oh |