| abstract |
The present invention relates to compounds of the general formula which have metalloproteinase inhibitory activity, preferably wherein X is imino or -N (C 1 -C 3 alkyl); Y1 and Y2 are oxygen; Z-SO2N (R6) - wherein R6 is hydrogen, alkyl, benzyl or pyridylmethyl; The valence line; R2 is hydrogen or optionally substituted (cyclo) alkyl, (cyclo) heteroalkyl or aryl; R3 and R4 are hydrogen or methyl; R5 is mono-bi- or tricyclic, optionally substituted, cycloalkane, aromatic, heterocycloalkane or heteroaromatic; and m is 1 and their salts or in vivo hydrolysable prodrug derivatives, their use and pharmaceutical compositions containing them. HE |