| abstract |
The present invention relates to compounds of the general formula (s) for use in the treatment of a condition (s) associated with p38 chromate activity wherein R3 is hydrogen, halogen, methyl, perfluoromethyl, methoxy, cyano or -NH2; X is -O-, -OC (= O) -, -S-, -S (= O) -, -SO 2 -, -C (= O) -, -CO 2 -, -NR 10 -, -NR 10 C (= O). ), -NR10C (= O) NR11-, -NR10CO2, -NR10SO2, -NR10SO2NR11-, -SO2NR10, -C (= O) NR10, halogen, nitro or cyano, or X is absent; Z is -O-, -S-, = N, or = CR20-, wherein when Z = CR20-, this atom may be taken together with R4 and R5 to form an optionally substituted bicyclic aryl or heteroaryl group; R1 is hydrogen, -CH3, -OH, -OCH3, -SH, -SCH3, and the like, and halogen, nitro or cyano; R2 is a) hydrogen, provided that R2 is other than hydrogen when X is a group of the general formula; b) optionally substituted alkyl, alkenyl, or alkynyl; c) optionally substituted aryl or heteroaryl; and d) optionally substituted heterocyclic or cycloalkyl; or e) R2 is absent when X is halogen, nitro or cyano; (i) R 4 is substituted aryl, heteroaryl or optionally substituted bicyclic 7-11 membered saturated or unsaturated carbocyclic or heterocyclic ring, and R 5 is hydrogen, alkyl or substituted alkyl, with the proviso that when Z is O or S, R 5 is absent or ii) together with R 4 and R 5a Z form an optionally substituted bicyclic 7-11-memberedaryl or heteroaryl group; R6 is hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic or other group and general compounds, and pharmaceutically acceptable salts, prodrugs, solvates, and uses thereof. The invention also relates to pharmaceutical compositions containing the compounds. SHE |