| abstract |
The present invention relates to compounds of formula (I), to their use in the prevention or prevention of fungal infections, to compositions containing the above compounds and to the preparation of the above compounds. In formula (I), R1 is fluoro, chloro or bromo, cyano, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, cycloalkyl or cycloalkenyl, -CH2CN or -CH2 (C = O) R5. a group of formula; R2 and R3 are hydrogen, fluorine or chlorine or methyl; R4 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl group may be substituted by halogen, alkoxy, cycloalkyl, aryl or heteroaryl. and azaryl and heteroaryl with one or more substituents, namely halogen, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, alkoxyalkyl, alkoxyalkoxy, cyano, nitro, hydroxyl or isothiocyanato, C (= O) R6, -C (= NR6) R6, -S (On) R6, where n is 0, 1 or 2, or aryl, aryloxy, heteroaryl or heteroaryloxy; R5 is hydrogen, alkyl or -OR7; A is aryl or heteroaryl which, with one or more substituents, namely halogen, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, alkoxyalkyl, alkoxyalkoxy, cyano, nitro, hydroxyl or isothiocyanate. -C (= O) R6, -C (= NR6) R6 or -S (On) R6, where n is 0, 1 or 2, or aryl, aryloxy, substituted aryloxy, heteroaryl or they may be substituted by heteroaryloxy; Z is -C (= O) R6, -C (= S) R6, -P (= O) (R6) 2 or -P (= S) (R6) 2. SHE |