http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0303729-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84b85f529049ce3987890738559fa556 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2001-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f67d82e7ee1c74198b4daaf70dff6f92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d472405e3e11796a4502b9468e556b91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3c9d5eb73970b0bcda893c0ac1741d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b36ef94f736ccb2b8ac53ed66ac990be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd6cce1b0a5fa670d96ff8f2782c3a79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08e0a8a95d9aa650f33d7f63e74a81ad |
| publicationDate | 2004-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0303729-A2 |
| titleOfInvention | Acridine derivatives and their use as medicaments and a method for their preparation |
| abstract | The present invention relates to novel heteroaryl derivatives of the general formula (I) and to their use in the preparation thereof, in particular for the treatment of tumors. In formula I, R, R 1, R 2, R 3 are optionally selected from the group consisting of 1-9. acridine carbon atoms, the same or different, independently of one another hydrogen, straight or branched C2-C8 alkyl, C3-C7 cycloalkyl, straight or branched C1-C8 alkylcarbonyl, preferably acetyl, straight or branched C 8 -C 8 alkoxy, halogen, aryl (C 1 -C 8) alkoxy, preferably benzyloxy or phenylethoxy, nitro, amino, mono- (C 1 -C 4) alkylamino, di- (C 1 -C 4) alkylamino ), C 1 -C 8 alkoxycarbonylamino, (C 1 -C 6 alkoxycarbonylamino) - (C 1 -C 8 alkyl), cyano, straight or branched cyano (C 1 -C 6 alkyl), carboxy, C 8 -C 8 alkoxycarbonyl, C 1 -C 4 alkyl substituted with one or more fluorine atoms, preferably trifluoromethyl, carboxy-C 1 -C 8 alkyl or C 1 -C 8 alkoxycarbonyl-C 1 -C 6 alkyl, C 6 -alkenyl, preferably allyl, 2-6 C 1 -C 4 alkynyl, preferably ethynyl or propargyl, linear or branched cyano (C 1 -C 6 alkyl), preferably cyanomethyl, aryl, wherein the aryl radical is unsubstituted or substituted with one or more identical or different substituents selected from the group consisting of halogen, straight and branched; C 8 -C 8 alkyl, C 3 -C 7 -cycloalkyl, carboxy, straight or branched chain. C1-C8 alkoxycarbonyl, preferably t-butoxycarbonyl, trifluoromethyl, hydroxy, straight or branched C1-C8 alkoxy, preferably methoxy or ethoxy, benzyloxy, nitro, amino, mono- (C1-C4) alkylamino) , di- (C 1-4 alkylamino), cyano, or straight or branched cyano (C 1-6 alkyl) groups. Z is oxygen or sulfur, wherein the acridine heterocycle substituted radical of formula (a) is acridine ring system 1-9. carbon atoms; P, Q independently of one another may be oxygen or two hydrogen atoms (i.e., -CH 2 -); X is N or C-R5 wherein R5 is hydrogen or C1-C6 alkyl; n, m is independently an integer from 0 to 3, provided that when n = 0, X is -CR 5 R 5 where R 5 and R 6 are each independently hydrogen or C 1-6 alkyl and wherein C = Z a nitrogen atom adjacent to the group is substituted with a hydrogen atom or a C 1-6 alkyl group. SHE |
| priorityDate | 2000-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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