| abstract |
The present invention relates to compounds of formula I wherein R is, among others, CN, R1 is R4, Ar, Ar1 or X, R2 is substituted phenyl, R3 is CHal3, OCOA or (3) R 4 is optionally substituted C 1 -C 20 alkyl, A is H or C 1 -C 20 alkyl, A 'is C 1 -C 10 alkyl, Ar is optionally substituted phenyl or naphthyl, Ar' is ( CH2) n-Ar, Het is a monocyclic or bicyclic, saturated, unsaturated or aromatic, optionally substituted heterocycle containing 1-4 N, O and / or S atoms, X is (CH2) nY, Y is COA- or a group of Formula 4, Hal is F, Cl, Br or I, n is 1, 2, 3, 4, 5 or 6, and m is 0 or 1, and pharmaceutically acceptable salts and solvates thereof. . The present invention relates to a process for the preparation of the compounds of the invention, to the use of the compounds according to the invention as a medicament and to a pharmaceutical composition containing the compounds according to the invention. SHE |