| abstract |
Field of the Invention The present invention relates to substituted 1-amino-butan-3-ol derivatives of formula I, to the preparation of these compounds, to pharmaceutical compositions containing them, and to the use of substituted 1-amino-butan-3-ol derivatives of formula I in the preparation of pharmaceutical preparations. It applies. In which R 1 and R 2 together form a - (CH 2) 2 - 9 ring optionally substituted by straight or branched, saturated or unsaturated, unsubstituted or singly or multiply substituted aryl; R 3 and R 4 are independently straight or branched, saturated or unsaturated, unsubstituted or singly substituted C 1-6 alkyl; C3-6cycloalkyl; or phenyl, benzyl or phenyl ethyl; or R 3 and R 4 together form a CH 2 CH 2 OCH 2 CH 2, CH 2 CH 2 NR 22 CH 2 CH 2, or (CH 2) 3-6 ring; R5 is saturated or unsaturated, straight or branched, unsubstituted or singly substituted C1-10 alkyl; C3-9cycloalkyl; aryl; heteroaryl; Aryl attached via an alkyl group of 1-3 carbon atoms; C 3 -C 10 cycloalkyl attached via saturated or unsaturated C 1-3 alkyl; or heteroaryl bonded via saturated or unsaturated alkyl having 1 to 3 carbon atoms, wherein each aryl, heteroaryl, and cycloalkyl group may be unsubstituted or substituted with one or more independent substituents; R6 is hydrogen; or unsubstituted or singly or multiply substituted aryl or heteroaryl; and R7 is halogen, trifluoromethyl; straight or branched, saturated or unsaturated, unsubstituted or singly or multiply substituted C1-6 alkyl; saturated or unsaturated, unsubstituted or singly or multiply substituted C 3-9 cycloalkyl; unsubstituted or singly or multiply substituted aryl or heteroaryl; or unsubstituted or mono- or polysubstituted aryl, C 3-9 cycloalkyl or heteroaryl bonded via saturated unsaturated C 1-3 alkyl. HE |