| abstract |
NonAr in the general formula (I) of the compounds of the invention is a non-aromatic 5-7 membered ring containing 1 or 2 nitrogen atoms or an azabicyclooctane ring, HetAr being a 5 or 6 membered heteroaromatic ring containing 1 to 3 nitrogen atoms, or isoxazolyl, thiazolyl, quinoline, , a quinazolinyl group, a purinyl group, a pteridinyl group, a benzimidazolyl group, a pyrrolopyrimidinyl group or an imidazopyridinyl group, which may be optionally substituted with 1 or 2 identical or different substituents, wherein the substituent alkyl group, cyclopropylethynyl, phenylethynyl, heteroarylethynyl, -N- (alkyl) - (alkyl) -, nitro, (C 1-2) alkyl - (C 1-2 alkyl) -NCH 2 -, (alkyl) HNCH 2 -, Si (CH 3) 3. -C- or NH 2 C (O) - k A is - (C0-C4) alkyl, B is aryl (CH2) 0-3-OC (O) -, heteroaryl (CH2) 1-3-OC (O) -, indanyl (CH2). 0-3-OC (O) -, aryl (CH2) 1-3-C (O) -, aryl-cyclopropyl-C (O) -, heteroaryl-cyclopropyl-C (O) -, heteroaryl (CH2) 1- 3-C (O) -, aryl (CH2) 1-3-, heteroaryl (CH2) 1-3-, aryl (CH2) 1-3-NH-C (O) -, aryl (CH2) 1-3- NH-C (NCN) -, aryl (CH2) 1-3-SO2- or heteroaryl (CH2) 1-3-SO2-, which may be optionally substituted on the aryl or heteroaryl group with 1 to 5 identical or different substituents, wherein the substituent is alkyl, cycloalkyl, alkoxy, trifluoromethyl, bromine, fluoro or chloro, X is hydrogen, hydroxy, fluoro, alkyl, alkoxy, or amino, or X is taken together with an adjacent bond = Ok. The present invention relates to pharmaceutical compositions containing the above compounds. HE |