| abstract |
FIELD OF THE INVENTION The present invention relates to fused ring compounds of formula (I), to their preparation, and to nuclear hormone receptor-related disorders; including compounds for the treatment of cancer and immune disorders. Compounds of the formula or a salt thereof, wherein G is aryl or heterocyclo, the group is mono- or polycyclic, optionally substituted at one or more positions; E is -C = Z 2, -CR 7 R 7, -SO 2, -P = OR 2 or -P = OOR 2; Z 1 is -O-, -S-, -NH- or -NR 6 -; Z2 is oxygen, sulfur, -NH- or -NR6-; A1 = CR7 or nitrogen; A2 is -CR7- or N; Y is JJ '-J <, where J is - (CR 7 R 7') n and n = 0-3, J 'is bond or oxygen, sulfur, -S = O, -SO 2, -NH, -NR 6, -C = O, -OC = O, -NR 1 C = O, -CR 7 R 7, -C = CR 8 R 8 ', -R 2p = O, -OPOOR 2, -OPO 2, -OSO 2, -C = N, -NHNH, -NHNR 6, -NR 6 NH, -N = N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, aryl or substituted aryl, and J <is - (CR 7 R 7 ') n, n is 0-3, where Y is not knitting; W is -CR 7 R 7 '-CR 7 R 7', -CR 8 = CR 8 ', = CR 7 R 7' -C = O, -NR 9 -CR 7 R 7 ', -N = CR 8, -N = N-, -NR 9 -NR 9', cycloalkyl or substituted cycloalkyl. -, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, aryl or substituted aryl; Q is hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or arylalkyl, arylalkyl or arylalkyl, arylalkyl or arylalkyl; substituted alkynyl, aryl or substituted aryl, heterocyclo or substituted heterocyclo, halogen, -CN, -R 1 OC = O, -R 4 C = O, -R 5 R 6 NC = O, HOCR 7 R 7 '-, nitro, -R 10 OCH 2, - R10, -NH2, -C = OSR1, SO2R1 or -NR4R5; M is a bond, -O, -CR7R7 'or -NR10, and M' is a bond or -NR10, provided that at least one of M or M 'is a bond; L is a bond, - (CR7R7 ') n, -NH, -NR5 or -N (CR7R7') n, wherein n is 0-3; HE |