| abstract |
The present invention relates to compounds of formula I wherein: R1 is selected from the group consisting of hydrogen, amino, alkyl, alkenyl, aminoalkyl, aryl, arylalkyl, heterocyclyl and cycloalkyl, which may be substituted; W is oxygen, sulfur or = NR ', Y is oxygen, sulfur, -NH- or -N- (C 1 -C 6 alkyl), Z is oxygen, sulfur or -NR 7, n is 1 to 1 Z is an integer from 0 to 7, Z1 is -CR8R9, A is an aromatic or non-aromatic, heterocyclic or non-heterocyclic ring system, is an integer from 0 to 7, R2 is preferably alkyl or halogen, R3 is hydrogen, alkyl, alkenyl, alkynyl or formula (a), and racemic forms, isomers, N-oxides and therapeutics are also possible and pharmaceutically acceptable salts thereof which are useful for the specific inhibition of type 13 matrix metalloprotease. The invention also relates to the preparation of compounds. SHE |