| abstract |
The present invention relates to compounds of the formula I, their solvates and / or their hydrates, which exhibit affinity and selectivity for V1b arginine-vasopressin receptors or V1b and V1a arginine-vasopressin receptors. The present invention also relates to a process for the preparation of said compounds, to intermediates of formula (II) used in their preparation, to pharmaceutical compositions containing said compounds, and to their use in the preparation of medicaments. Compounds of formula (I) wherein: n is 1 or 2; W is oxygen or sulfur; R1 is -halo; (C1-C4) alkyl; (C1-C4) alkoxy; trifluoromethyl; trifluoromethoxy radical; R2 is hydrogen; halogen; (C1-C4) alkyl; (C1-C4) alkoxy; trifluoromethyl group; or R2 is in the 6-position of the indol-2-one ring and R1 and R2 together form a one-trimethylene group; R3 is halogen; hydroxyl; (C1-C2) alkyl; (C1-C2) alkoxy; trifluoromethoxy radical; R4 is hydrogen, halogen; (C1-C2) alkyl; (C1-C2) alkoxy; or R 3 is in the 2-position of the phenyl group, R 4 is in the 3 position of the phenyl group and R 3 and R 4 together form a methylenedioxy group; R5 is ethylamino; dimethylamino group; 1-azetidinyl; (C1-C2) alkoxy; R6 is (C1-C4) alkoxy; R7 is (C1-C4) alkoxy; HE |