http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0303025-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C257-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C257-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-02 |
| filingDate | 2001-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20490b5c864b0eabc10bbe60eecda3d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f243316e9d9a80d554dd33c525d824f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19ab0398c514b1a486521b689bccddad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e28dfc89231c3099160abad4f130e564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09f3070675cf449db1ffed0d9d584736 |
| publicationDate | 2003-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0303025-A2 |
| titleOfInvention | Process for the preparation of arylethanoldiamines |
| abstract | The present invention relates to aryl ethanoldiamine derivatives of the formula IA and pharmaceutically acceptable salts thereof, wherein R 1 is aryl, phenoxymethyl or 5- or 6-membered heteroaromatic, each optionally substituted with one or more substituents selected from halo, C 1-6 alkoxy, C 1-6 alkyl, nitro, cyano, trifluoromethyl, -NR 8 R 9 and -NHSO 2 R 8; R 2 is hydrogen or C 1-6 alkyl, R 3 is hydrogen or C 1-6 alkyl, X 1 and X 2 are each other; independently (a) hydrogen, (b) C 1-6 alkyl-CO, or (c) aryl-CO optionally substituted with halo or C 1-6 alkyl, provided that when one is (b) or (c) , then the other hydrogen atom (a); R 4 is (a) phenyl substituted with one or more substituents selected from C 1-6 alkyl, halogen, trifluoromethyl, C 1-6 alkoxy, -CO 2 H and -CO 2 R 8; or (b), phenoxymethyl or a 5- or 6-membered heteroaromatic group optionally substituted with one or more substituents selected from the group consisting of C 1-6 alkyl, halogen, trifluoromethyl, C 1-6 alkoxy, -CO 2 H, -CO 2 R 8, CN, NO2, hydroxymethyl and -CONHR8; or (c) a group of formula (W) wherein A is aryl or a 5- or 6-membered heteroaromatic group, R 5 is cyano, tetrazol-5-yl, -CO 2 H, or-CO 2 R 8; R 6 and R 7 are independently hydrogen, C 1-6 alkyl, -CO 2 H, -CO 2 R 8, cyano, tetrazol-5-yl, halogen, trifluoromethyl or C 1-6 alkoxy, or when R 6 and R 7 are adjacent to carbon atoms, then R 6 and R 7 together with the carbon atoms to which they are attached form a fused ring containing one or two nitrogen atoms, oxygen or sulfur atoms in the 5- or 6-membered case; each R 12 is independently C 1-6 alkyl, halogen, trifluoromethyl or C 1-6 alkoxy, and n is an integer from 0 to 4; and R8 and R9 are independently C1-C6alkyl. The compounds of the invention are useful as atypical beta-adrenoceptor agonists, including for the treatment of high blood sugar. HE |
| priorityDate | 2001-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 160.