| abstract |
The present invention relates to xanthine phosphodiesterase vinyl inhibitors of the general formula wherein R1 and R2 are independently optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, heteroaryl or other groups; R3 is optionally substituted aryl or heteroaryl, subject to certain limitations; R 4 is optionally substituted cycloalkyl, cycloalkenyl or heterocycloalkyl, in particular compounds of the general formula and their use in pharmaceutical compositions for the treatment of male and female sexual dysfunctions or other physiological disorders. The invention also relates to a process for the preparation of the compounds. SHE |