| abstract |
The present invention relates to a combined vaccine providing broad protection against meningococcal disease caused by Neisseria meningitidis. Avacina consists of four distinct polysaccharide protein conjugates that have been formulated into a single vaccine dose. Purified capsular polysaccharides derived from serogroups A, C, W-135 and Y of ANeisseria meningitidis are chemically activated and selectively bound by a carrier bond to a carrier protein to form polysaccharide-protein conjugates capable of eliciting long-term immunity in a variety of N. meningitidis strains in children and adults. HE |